T2 Diseases

Interactive e-learning resource aiming to improve the diagnosis and management of T2 diseases as a long term conditions for children and adults.

Module focused on the T2 complex endotype aiming to define and understand the pathogenesis of T2 immune-inflammatory response, its biomarkers and visible properties, adapted to specialized care (specialists in allergy and clinical immunology, pneumology, ENT, dermatology, paediatrics).

Introduction to the T2 module

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This first educational module focuses on the T2 complex endotype and aims to define and understand the pathogenesis of T2 immune-inflammatory response, its biomarkers and visible properties, adapted to specialized care (specialists in allergy and clinical immunology, pneumology, ENT, dermatology, paediatrics).

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Physiopathology of T2 immune response

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The lecture provides an in depth description of the allergen-specific and general type 2 immune response with tissue and blood eosinophilia, excessive and bad mucus production, tissue remodeling, barrier disfunction, microbial dysbiosis, the role of key cytokines (IL4, IL13, IL5, IL9, TSLP, IL33, IL25).

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T2 Biomarkers

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The lecture provides an exhaustive description of diagnostic, monitoring, response, predictive and prognostic biomarkers for the T2 immune response, with indications when and how to use in clinical practice followed by an illustrative case report on the value of T2 biomarkers for a non-response to biological intervention in severe asthma.

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T2 Clinical Phenotypes in the Lung

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The lecture provides an overview of T2 asthma, from pathogenesis and biomarkers to clinical characteristics and co-morbidities. The inflammatory circuitry in T2 asthma involving allergy, epithelial dysfunction and T2 immune response and its modulation by viral infections and pollutants is discussed in depth. Three patient cases guide the learner in understanding how to personalize treatment of T2 asthma in the clinic

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T2 clinical phenotypes in the skin

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The lecture discusses atopic dermatitis pathogenesis with a focus on the use of biomarkers to separate clinical phenotypes as a basis for the personalized approach. The value of skin profiling for cytokines, barrier function and microbiome as a basis of treatment decisions in the clinic is further discussed. 

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T2 clinical phenotypes in the GI tract

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The lecture describes the two major types of gastro-intestinal inflammatory diseases, IgE and non-IgE, with a special focus on eosinophilic esophagitis, gastritis and colitis.



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Type 2 chronic rhinosinusitis

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The lecture describes the two types of chronic rhinosinusitis, with and without nasal polyps, linking its pathogenesis(the complex interplay between the immune-inflammatory response, epithelial barrier defect, mucus and coagulation abnormalities and microbiome) to biomarkers guiding treatment decisions.


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T2 clinical endotypes - pediatric aspects

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The lecture describes the role of T2 inflammation in the transition from recurrent wheezing to childhood asthma, asthma exacerbations and treatment response. The impact of early life exposures is discussed in depth. Several case studies guide de leaner for understanding personalized decisions in pediatric asthma.

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