Introduction to the T2 module
This first educational module focuses on the T2 complex endotype and aims to define and understand the pathogenesis of T2 immune-inflammatory response, its biomarkers and visible properties, adapted to specialized care (specialists in allergy and clinical immunology, pneumology, ENT, dermatology, paediatrics).
Physiopathology of T2 immune response
The lecture provides an in depth description of the allergen-specific and general type 2 immune response with tissue and blood eosinophilia, excessive and bad mucus production, tissue remodeling, barrier disfunction, microbial dysbiosis, the role of key cytokines (IL4, IL13, IL5, IL9, TSLP, IL33, IL25).
T2 Biomarkers
T2 Clinical Phenotypes in the Lung
T2 clinical phenotypes in the skin
The lecture discusses atopic dermatitis pathogenesis with a focus on the use of biomarkers to separate clinical phenotypes as a basis for the personalized approach. The value of skin profiling for cytokines, barrier function and microbiome as a basis of treatment decisions in the clinic is further discussed.
T2 clinical phenotypes in the GI tract
The lecture describes the two major types of gastro-intestinal inflammatory diseases, IgE and non-IgE, with a special focus on eosinophilic esophagitis, gastritis and colitis.
Type 2 chronic rhinosinusitis
The lecture describes the two types of chronic rhinosinusitis, with and without nasal polyps, linking its pathogenesis(the complex interplay between the immune-inflammatory response, epithelial barrier defect, mucus and coagulation abnormalities and microbiome) to biomarkers guiding treatment decisions.
T2 clinical endotypes - pediatric aspects
