Food Allergy and Anaphylaxis: Latest updates in the diagnosis and management of food allergy
Already registered?
Log in now.
Food allergy can result in considerable morbidity, impact negatively on quality of life, and prove costly in terms of medical care. It is mostly IgE-mediated and a chronic disease affecting up to 4% of the European population.
This eLearning product delves into the epidemiology and economics; the needs, perspectives and best practices for food allergic patients; allergens and their detection; the role of the skin barrier and skin manifestations of food allergy; latest updates in diagnosis and management; and the immune processes in the disease.
Get eLearning! Gain a deeper knowledge of food allergy and anaphylaxis by completing one or more of EAACI’s courses on this topic.
To learn about latest updates in the diagnosis and management of food allergy. In particular, the module spans:
- Interpretation of food allergen bioanalytical laboratory results: note of caution, what to expect and guidance.
- The nasal exposure test as a diagnostic tool to replace oral food challenges.
- A study on the distinction between peanut allergy and tolerance via in vitro characterization of human antibodies.
- The main characteristics, features and management of the non-IgE-mediated food allergies.
Michael Walker
The pitfalls of food testing and electronic allergen information provision
Sònia Gelis
The usefulness of Nasal Allergen Challenge in the diagnosis of shrimp allergy
Anna Ehlers
Heavy chain complementarity-determining region 3 of peanut 2S albumin specific antibodies: Distinction between peanut allergy and tolerance
Simona Barni
Clinical aspects of non-IgE mediated food allergy
Key:
Complete
Next
Failed
Available
Locked
The pitfalls of food testing and electronic allergen information provision
Recorded 10/17/2020
Recorded 10/17/2020
Assessment: The pitfalls of food testing and electronic allergen information provision
10 Questions | 2 attempts | 10/16 points to pass
10 Questions | 2 attempts | 10/16 points to pass
The usefulness of Nasal Allergen Challenge in the diagnosis of shrimp allergy
Recorded 10/17/2020
Recorded 10/17/2020
Educational Objectives:
This small talk summarizes a research work that has been carried out at the Hospital Clínic of Barcelona with 54 subjects, and which arises from the need for clinicians to be able to reliably diagnose subjects with suspected food allergy, without having to perform an oral food challenge.
The future of allergology in the field of food allergy depends on the exhaustive knowledge of all the allergens that can be found in a food, as well as the clinical significance that each of them may have. It is likely that in the future the exclusive use of component-resolved diagnosis (CRD) will allow us to diagnose, anticipate severity, or estimate cross-reactivity with other foods . But this future is still a long way off, especially in some food families, such as seafood, a group in which the CRD is very poorly developed.
Therefore, we are looking for diagnostic tools that allow us to replace oral food challenges, the gold standard test, the only one that establish a diagnostic certainty, but carry out the risk of triggering allergic reactions, sometimes severe.
Assessment: The usefulness of Nasal Allergen Challenge in the diagnosis of shrimp allergy
5 Questions | 2 attempts | 5/5 points to pass
5 Questions | 2 attempts | 5/5 points to pass
Heavy chain complementarity-determining region 3 of peanut 2S albumin specific antibodies: Distinction between peanut allergy and tolerance?
Recorded 10/17/2020
Recorded 10/17/2020
Educational Outcome
By watching my talk, the following can be learned:
- Specific IgE against the major peanut allergens Ara h 2 and 6 is a good predictor for clinically relevant peanut sensitisation. However, there are overlaps of sIgE levels between peanut allergic and peanut sensitised but tolerant patients, making accurate diagnostics difficult. This can lead to unwanted food restrictions. (Slide 3)
- The method described in this talk is a suitable way to produce specific human monoclonal antibodies from peripheral blood in the laboratory (Slide 4)
- Results: differences on DNA level between Ara h 2 and/or 6 specific antibodies derived from peanut allergic and peanut tolerant but sensitised patients (irrespective of their isotype): VH family gene usage and HCDR3 region motifs. This might be the basis for a novel in vitro diagnostic strategy in those patients described above.
- Discussion: only a small number of the isolated B cells were IgE+, potentially due to dominant class-switching to IgE in the tissue, low BCR surface expression of plasma blast-like IgE+ B-cells and the extreme low abundance of IgE+ B-cells within the circulation (see literature below). The selected antibodies are still interesting for research as there is evidence that the IgE memory is dominantly embedded into the IgG memory compartment.
- Nevertheless, for a new diagnostic strategy it might not be important to which isotype these specific B cells belong as long as they can correctly predict the clinical outcome. This is a first study with a small patient group and these results have to be validated in a larger cohort.
Assessment: Heavy chain complementarity-determining region 3 of peanut 2S albumin specific antibodies: Distinction between peanut allergy and tolerance
4 Questions | 2 attempts | 4/4 points to pass
4 Questions | 2 attempts | 4/4 points to pass
Clinical aspects of non-IgE mediated food allergy
Recorded 10/17/2020
Recorded 10/17/2020
Educational Objectives:
- Non-IgE-mediated food allergies comprise a spectrum of diseases with peculiar features affecting infants and young children. The most prominent features of these diseases are symptoms that affect mainly the gastrointestinal tract. It is of paramount importance to provide the clinicians with the tools for non-IgE-mediated food allergy recognition in clinical practice to avoid the misdiagnosis with unnecessary laboratory tests and detrimental treatments.
- The aim of my talk is to underline the main characteristics of the non-IgE-mediated food allergies (food protein-induced allergic proctocolitis, food protein-induced enterocolitis syndrome and food protein-induced enteropathy).
Educational Outcome:
At the end of this activity, participants should be able to:
1. Describe the clinical characteristics of patients with food protein induced allergic proctocolitis, food protein induced enterocolitis syndrome and food protein enterocolitis.
2. Identify the criteria for food protein induced allergic proctocolitis, food protein induced enterocolitis syndrome and food protein enterocolitis diagnosis
3. Describe the management of food protein induced allergic proctocolitis, food protein induced enterocolitis syndrome and food protein enterocolitis
Assessment: Clinical aspects of non-IgE mediated food allergy
5 Questions | 2 attempts | 5/5 points to pass
5 Questions | 2 attempts | 5/5 points to pass