Type 2 chronic rhinosinusitis - Presentation

The lecture describes the two types of chronic rhinosinusitis, with and without nasal polyps, linking its pathogenesis(the complex interplay between the immune-inflammatory response, epithelial barrier defect, mucus and coagulation abnormalities and microbiome) to biomarkers guiding treatment decisions. The inflammatory heterogeneity in CRS impact on clinical phenotypes and disease severity is discussed in depth and is exemplified nicely with clinical cases.