T2 clinical phenotypes in the skin - Presentation with Live Discussion & Q&A Webcast
The lecture discusses atopic dermatitis pathogenesis with a focus on the use of biomarkers to separate clinical phenotypes as a basis for the personalized approach. The value of skin profiling for cytokines, barrier function and microbiome as a basis of treatment decisions in the clinic is further discussed. Clinical cases facilitate the understanding clinical phenotyping in atopic dermatitis. Another atopic co-morbidity, alopecia areata, is also presented as an example of T2 driven inflammation in the skin. The combination between T2 and T17 and T1 immune response as a basis of chronicity is explained with examples from targeted interventions in clinical trials and in the clinic.